Manitouwadge Museum is operated by Manitouwadge Archival& Historical Society, a volunteer organization created in 2002. The museum followed in 2004, now located in the former Anglican church at 52 Adjala Avenue. It used to be called Church of the Holy Spirit.
The facility also operates as the Manitouwadge Tourism Information Centre.
Threads, a thrift shop, operates in the basement, with profits dedicated to the museum.